Hematology Consults | An Expanding Clinical Landscape of GVHD – Module 2
Steroid-Refractory Acute and Chronic GVHD
There is little guidance about choosing the most appropriate therapy for patients with graft vs host disease (GVHD) after undergoing an allogeneic hematopoietic stem cell transplantation (alloHSCT). Until the recently, steroids were the only agents with proven ability to treat patients with GVHD. However, GVHD often becomes steroid resistant or refractory. In response to this problem, the Janus kinase (JAK) inhibitor, ruxolitinib, and the Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib, were studied, then approved as second-line treatments. A large number of other agents are also available to treat patients with GVHD, though all of these agents have relatively weak efficacy. The choice of therapy is often dictated by personal and institutional experience and patient-specific comorbidities and tolerance. Using patient cases, this activity reviews the safety and efficacy of emerging agents for the management of patients with GVHD and illustrates appropriate therapy selection for patients experiencing steroid-refractory acute and chronic GVHD.
Hematology Consults.com is a real-world focused, interactive, case-based, e-learning platform. Here, you will find interactive, written, enduring, Continuing Education (CE) modules accredited by the Institute for Johns Hopkins Nursing, developed and executed with clinical oversight by top experts in many hematology specialties. Activities are available on a wide range of topics, and allow participants the opportunity to apply the information learned in day-to-day patient care.
Jonathan Moreira, MD
Assistant Professor of Medicine
Robert H. Lurie Comprehensive Cancer Center
Department of Medicine, Division of Hematology/Oncology
Northwestern University Feinberg School of Medicine
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- 0.50 ANCC
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