Hematology Consults | The Current Landscape of GVHD – Module 1
Integrating Targeted Agents into the Systemic Treatment of Acute and Chronic Steroid-Refractory Grafts vs Host Disease
Allogeneic hematopoietic stem-cell transplantation (alloHSCT) is favored for treating patients with acute myeloid leukemia, acute lymphocytic leukemia, and myelodysplastic syndromes. AlloHSCTs rely on the immunoreactivity of the donor graft for a potent antitumor response, however, alloHSCTs are associated with acute and chronic graft versus host disease (GVHD), which can affect many different organs and tissues. Approximately half of patients who undergo alloHSCTs develop GVHD that requires treatment, and approximately 10% of patients die of GVHD. Patients may develop acute and/or chronic GVHD as a result of dysregulated immune responses that lead to tissue injury, inflammation, and possibly destruction. Recognizing that specific immune signaling pathways are activated in patients with GVHD has led to the development of new therapeutic agents. Using patient cases, this activity will review the pathophysiology of GVHD and the recent emergence of ibrutinib and ruxolitinib for treating patients with GVHD.
Hematology Consults.com is a real-world focused, interactive, case-based, e-learning platform. Here, you will find interactive, written, enduring, Continuing Education (CE) modules accredited by the Institute for Johns Hopkins Nursing, developed and executed with clinical oversight by top experts in many hematology specialties. Activities are available on a wide range of topics, and allow participants the opportunity to apply the information learned in day-to-day patient care.
Jonathan Moreira, MD
Assistant Professor of Medicine
Robert H. Lurie Comprehensive Cancer Center
Department of Medicine, Division of Hematology/Oncology
Northwestern University Feinberg School of Medicine
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- 0.50 ANCC
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